About Candesartan Protects Against Limb Ischemia in Diabetic Rats: Angiogenic and Anti-Inflammatory Mechanisms via PI3K-Akt-eNOS-VEGF Signaling | Knowture Research Hub

About This Research Video

Peripheral arterial disease (PAD) is a serious vascular complication highly prevalent among Type 2 Diabetes Mellitus (T2DM) patients, often progressing to critical limb ischemia (CLI) a debilitating and potentially limb-threatening condition. Currently, pharmacotherapy options are limited.

In this preclinical research video, a team from Mansoura University, Egypt evaluates the vascular protective effects of Candesartan, an angiotensin II receptor blocker, in a diabetic CLI rat model. The study explores how Candesartan modulates PI3K-Akt-eNOS-VEGF signaling to reverse ischemic injury and promote angiogenesis.

 Watch now on Knowture’s Research Hub: https://knowture.mans.edu.eg/researches/ 

 Who Should Watch

This video is ideal for:

• • Cardiovascular medicine researchers.
  • Endocrinologists specialize in diabetic complications.
  • Translational pharmacology researchers.
  • Medical and pharmaceutical postgraduate students.
  • Healthcare policymakers and clinical vascular specialists.

Key Research Highlights

• • Diabetic rats with CLI showed impaired angiogenic signaling and increased inflammatory/apoptotic markers.
  • Candesartan treatment (10 or 30 mg/kg) enhanced reparative angiogenesis by elevating:
    • p-PI3K/PI3K
    • p-Akt/Akt
    • p-eNOS/eNOS
    • p-VEGFR2/VEGFR2
    • VEGF levels

Additional benefits:

• • Increased antioxidant HO-1 enzyme.
  • Reduced pro-inflammatory NF-κB, TNF-α, and apoptotic Caspase-3 markers.
  • Preserved muscle histology in ischemic tissues.

Why This Study Matters

This research highlights Candesartan’s potential as a future pharmacotherapy for diabetic CLI, a condition where surgical revascularization remains the only effective option. The study’s angiogenic and anti-inflammatory findings could pave the way for clinical trials in human subjects with Type 2 diabetes and PAD.

Full Research Publication

 Published via ScienceDirect:
Candesartan protects against unilateral peripheral limb ischemia in type-2 diabetic rats

 Scientific Context and Supporting References

This study addresses a critical gap in diabetes-related vascular therapeutics, reinforcing the potential clinical utility of angiotensin II receptor blockers (ARBs) beyond hypertension management.

Further reading:

• • • Criqui MH, Aboyans V. Epidemiology of PAD

About Knowture

Knowture is a postgraduate digital learning platform by Mansoura University, Egypt, providing specialized research publications, online postgraduate courses, and academic resources in medical sciences, public health, biotechnology, and environmental research.

Visit: https://knowture.mans.edu.eg