First Successful Aortic Valve and Outflow Tract Reconstruction Using the Modified Ross-Ozaki Technique | Knowture Research Hub

About This Research Video

Welcome to an in-depth exploration of pioneering cardiac surgery research from Mansoura University. In the urgent quest for more durable and biocompatible solutions in heart valve surgery, our latest study presents the first successful reconstruction of the aortic valve and ventricular outflow tracts using the Modified Ross-Ozaki procedure. This video presentation features a detailed surgical demonstration of how autologous tissues—without the use of any foreign materials—can be utilized to achieve long-term functional restoration of the left (LVOT) and right (RVOT) ventricular outflow tracts.

Traditional prosthetic valve replacements, although widely used, suffer from inherent drawbacks, including limited durability, lifelong anticoagulation therapy, a high risk of infection, and impaired hemodynamics. These limitations highlight the pressing need for innovative biological alternatives. The Ross-Ozaki technique combines two powerful surgical concepts: the Ross procedure, where the patient’s pulmonary valve replaces the diseased aortic valve, and the Ozaki procedure, where new valve cusps are fashioned from autologous pericardium. Together, these techniques form a fully autologous reconstruction approach that promises improved outcomes, physiological valve function, and reduced complications.

At the core of this advancement lies the use of patient-derived pericardial tissue, carefully prepared and shaped to form new valve cusps and reconstruct the outflow tracts. This video provides step-by-step surgical insights, from tissue preparation to valve implantation and postoperative assessment, offering a valuable learning resource for cardiothoracic surgeons and postgraduate trainees worldwide.

Who Should Watch

This research video is essential for:

• Cardiac Surgeons and Surgical Trainees: Interested in advanced techniques for valve repair and reconstruction.

• Cardiologists and Heart Specialists: Exploring innovative alternatives to prosthetic valves.

• Medical Researchers and Biomedical Engineers: Focused on autologous tissue engineering and heart valve design.

• Postgraduate Students: In cardiac surgery, cardiovascular sciences, and regenerative medicine.

• Policy Makers and Health Professionals: Seeking patient-friendly, cost-effective, and long-lasting solutions for valvular heart disease.

Key Research Highlights

• Introduction of the Modified Ross-Ozaki Procedure: A groundbreaking approach that unites the Ross and Ozaki operations for total autologous reconstruction.

• Use of Autologous Tissues: Demonstrates valve and outflow tract reconstruction using the patient’s pericardium—eliminating prosthetics.

• Step-by-Step Surgical Guidance: Covers harvesting, shaping, and suturing techniques essential for successful outcomes.

• Enhanced Physiological Valve Function: Achieves natural hemodynamics and growth potential in younger patients.

• Reduced Complications: Avoids long-term anticoagulation, lowers risk of prosthetic valve failure, and minimizes infection rates.

• Contribution to Future Standards of Care: Aligns with global efforts to develop sustainable, patient-centered surgical solutions.

Why This Study Matters

This research represents a paradigm shift in the field of cardiac surgery. By moving away from prosthetic implants and harnessing autologous tissues, the Modified Ross-Ozaki procedure offers:

• Durability and Longevity: Natural tissue growth potential and improved mechanical performance.

• Improved Quality of Life: Eliminates lifelong anticoagulant dependency.

• Reduced Healthcare Burden: Lower reoperation rates and fewer complications overtime.

• Innovation in Surgical Science: Provides new insights into regenerative cardiac surgery and tissue engineering.

• Global and National Relevance: Advances Mansoura University’s role in shaping patient-centered innovations aligned with modern cardiovascular care standards.